Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 5/20 | 0.32 |
| ▸ | NOS2 | P35228 | 5/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19593060 | 0.86 | NPC1 (0.35) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL19726965 | 0.85 | NOS2 (0.36) | NOS3NOS2RIPK2NOS1 | |
| SCHEMBL179483 | 0.80 | GAA (0.42) | NPC1RAB9AMAPTNOS3NOS2 | |
| SCHEMBL17923118 | 0.74 | NOS3 (0.47) | MAPTNOS3NOS2NOS1LMNA | |
| SCHEMBL18879383 | 0.70 | HSP90AA1 (0.39) | SMN1; SMN2 | |
| SCHEMBL780091 | 0.70 | NPC1 (0.43) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL13134422 | 0.69 | MKNK1 (0.50) | NPC1RAB9AMAPTNOS3NOS2 | |
| SCHEMBL18879382 | 0.69 | NOS3 (0.57) | NPC1RAB9AMAPTNOS3NOS2 | |
| SCHEMBL24653295 | 0.69 | NPC1 (0.48) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL21557594 | 0.69 | NPC1 (0.48) | NPC1RAB9AMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9655892-B2 | Certain chemical entities, compositions and methods | INTELLIKINE LLC (US) | 2017-05-23 | — | — | US | disclosed |