Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18879258 | 0.86 | NPC1 (0.36) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL780091 | 0.77 | NPC1 (0.43) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL13134422 | 0.77 | MKNK1 (0.50) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL17552745 | 0.76 | NPC1 (0.37) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL9967860 | 0.75 | GABRA1 (0.42) | NPC1RAB9ALMNAMAPT | |
| SCHEMBL21971675 | 0.74 | NPC1 (0.36) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL17552740 | 0.74 | RIPK1 (0.40) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL17469342 | 0.73 | NPC1 (0.35) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL12447064 | 0.71 | IDO1 (0.40) | NPC1RAB9ALMNAMAPK1CASP3 | |
| SCHEMBL17987324 | 0.71 | NPC1 (0.34) | NPC1RAB9ALMNAMAPK1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815839-B2 | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors | INCYTE CORPORATION (US) | 2017-11-14 | — | — | US | disclosed |