Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 6/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 5/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | VSIR | Q9H7M9 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15994111 | 0.81 | KDM5B (0.56) | KDM5CKDM5BKDM5AKDM6BKDM4A | |
| SCHEMBL19582240 | 0.80 | TERT (0.43) | KDM5CKDM5BSIRT2TERTKDM5A | |
| SCHEMBL16293301 | 0.79 | HRH4 (0.40) | KDM5CKDM5BSIRT2TERTKDM5A | |
| SCHEMBL16293030 | 0.79 | TMEM97 (0.56) | KDM5BSIRT2TERTVSIRCCNA2 | |
| SCHEMBL19582224 | 0.77 | NOS3 (0.49) | KDM5CKDM5BSIRT2TERTKDM5A | |
| SCHEMBL16293691 | 0.77 | KDM5B (0.43) | KDM5CKDM5BSIRT2TERTKDM5A | |
| SCHEMBL16305525 | 0.75 | TERT (0.44) | KDM5CKDM5BSIRT2TERTKDM5A | |
| SCHEMBL18860200 | 0.75 | SIRT2 (0.41) | KDM5CKDM5BSIRT2TERTKDM5A | |
| SCHEMBL16293032 | 0.75 | SIRT2 (0.40) | KDM5CKDM5BSIRT2TERTKDM4A | |
| SCHEMBL17984955 | 0.75 | SIRT2 (0.39) | KDM5CKDM5BSIRT2TERTKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170811-A1 | ETHYL PYRIDINE-4-CARBOXYLATE COMPOUND AS INHIBITOR OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |