Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.39 |
| ▸ | VSIR | Q9H7M9 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.36 |
| ▸ | KDM5C | P41229 | 4/20 | 0.36 |
| ▸ | KDM4A | O75164 | 2/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17984972 | 0.85 | ROCK1 (0.38) | SIRT2MEN1KMT2AKDM5BKDM5C | |
| SCHEMBL16293032 | 0.83 | SIRT2 (0.40) | SIRT2VSIRMAP4K4MEN1MAPT | |
| SCHEMBL16293030 | 0.76 | TMEM97 (0.56) | SIRT2VSIRMEN1KMT2AKDM5B | |
| SCHEMBL18880299 | 0.75 | KDM5C (0.43) | SIRT2VSIRMAP4K4KDM5BKDM5C | |
| SCHEMBL15994111 | 0.69 | KDM5B (0.56) | KDM5BKDM5CKDM4AKDM4BKDM5A | |
| SCHEMBL16305525 | 0.69 | TERT (0.44) | SIRT2TDP1KDM5BKDM5CKDM4A | |
| SCHEMBL133622 | 0.69 | MEN1 (0.64) | VSIRMEN1MAPTKMT2ATDP1 | |
| SCHEMBL19582240 | 0.68 | TERT (0.43) | SIRT2KDM5BKDM5CKDM4AKDM5A | |
| SCHEMBL16292675 | 0.68 | SIGMAR1 (0.41) | SIRT2KDM5BKDM5CKDM4AKDM4B | |
| SCHEMBL16292979 | 0.68 | CHRM2 (0.41) | SIRT2TDP1KDM5BKDM5CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160237037-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2016-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237037-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM1A, KDM3A | SIRT2 592/4885VSIR 3058/4885MAP4K4 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.