Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.35 |
| ▸ | CMA1 | P23946 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965706 | 0.80 | CMA1 (0.44) | CMA1HTTKMT2AMAPTGPR84 | |
| SCHEMBL6115321 | 0.78 | PARG (0.35) | GPR139CMA1HTTKMT2AMAPT | |
| SCHEMBL1847168 | 0.78 | GAA (0.49) | GPR139CMA1HTTKMT2AMAPT | |
| SCHEMBL1848895 | 0.72 | POLB (0.46) | HTTKMT2AGPR84MEN1 | |
| SCHEMBL1851878 | 0.71 | CMA1 (0.44) | CMA1HTTKMT2AMAPTMEN1 | |
| SCHEMBL18887412 | 0.70 | CMA1 (0.66) | CMA1 | |
| SCHEMBL1853120 | 0.64 | CMA1 (0.35) | GPR139CMA1HTTKMT2AMAPT | |
| SCHEMBL18900859 | 0.62 | GPR84 (0.52) | CMA1KMT2AMAPTGPR84MEN1 | |
| SCHEMBL20371663 | 0.61 | GPR84 (0.53) | GPR84 | |
| SCHEMBL3689406 | 0.60 | PGR (0.38) | KMT2AGPR84MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323991-B1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-05-31 | — | — | EP | disclosed |