Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18890669 | 0.76 | TDP1 (0.58) | MEN1KMT2AMAPTHTTCYP1A2 | |
| SCHEMBL19429663 | 0.74 | MEN1 (0.42) | MEN1KMT2AMAPTGAANPSR1 | |
| SCHEMBL849875 | 0.73 | MEN1 (0.77) | MEN1KMT2AMAPTGAANPSR1 | |
| SCHEMBL18570378 | 0.73 | MEN1 (0.48) | MEN1KMT2AMAPTGAANPSR1 | |
| SCHEMBL15478107 | 0.73 | GAA (0.59) | MEN1KMT2AMAPTGAANPSR1 | |
| SCHEMBL19005463 | 0.71 | RAB9A (0.46) | MEN1KMT2AMAPTGAANPSR1 | |
| SCHEMBL93283 | 0.70 | NPSR1 (0.55) | MEN1KMT2AMAPTGAANPSR1 | |
| SCHEMBL15484245 | 0.70 | MAPT (0.75) | MEN1KMT2AMAPTGAANPSR1 | |
| SCHEMBL27923493 | 0.70 | MEN1 (0.73) | MEN1KMT2AMAPTGAANPSR1 | |
| Methyl Alcohol SCHEMBL28397318 | 0.69 | ALDH1A1 (0.64) | MAPTGAALMNACYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657004-B2 | Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use | AGIOS PHARMACEUTICALS, INC (US) | 2017-05-23 | — | — | US | disclosed |