Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
| ▸ | PDE6G | P18545 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE6B | P35913 | 1/20 | 0.31 |
| ▸ | PDE6C | P51160 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10833230 | 0.81 | NQO2 (0.40) | ALDH1A1TLR8CA1CA2CA7 | |
| SCHEMBL3323208 | 0.76 | TLR8 (0.37) | ALDH1A1TLR8CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18894152 | 0.74 | DAO (0.36) | ALDH1A1TLR8CA2CYP1A2AURKA | |
| SCHEMBL18894190 | 0.74 | ALDH1A1 (0.34) | ALDH1A1TLR8CYP1A2AURKAALKBH5 | |
| SCHEMBL18894161 | 0.74 | ALDH1A1 (0.34) | ALDH1A1TLR8CYP1A2AURKAALKBH5 | |
| SCHEMBL1826324 | 0.74 | AURKA (0.35) | ALDH1A1TLR8CYP1A2AURKAALKBH5 | |
| SCHEMBL557928 | 0.72 | SMN1; SMN2 (0.36) | ALDH1A1BACE1 | |
| SCHEMBL18894202 | 0.70 | TSHR (0.33) | ALDH1A1TLR8CYP1A2CYP2C19AURKA | |
| SCHEMBL18894124 | 0.69 | ALDH1A1 (0.32) | ALDH1A1TLR8 | |
| SCHEMBL18894154 | 0.69 | ALDH1A1 (0.34) | ALDH1A1TLR8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136310-B2 | Iminotetrahydropyrimidinone derivatives as plasmepsin V inhibitors | UCB Biopharma SRL (BE) | 2021-10-05 | — | — | US | disclosed |
| US-20200283416-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | CELLTECH R&D LIMITED (GB) | 2020-09-10 | — | — | US | disclosed |
| US-10464932-B2 | Iminothiadiazinane dioxide derivatives as plasmepsin V inhibitors | UCB BIOPHARMA SPRL (BE) | 2019-11-05 | — | — | US | disclosed |
| US-20190040053-A1 | Iminothiadiazinane Dioxide Derivatives as Plasmepsin V Inhibitors | UCB BIOPHARMA SPRL (BE) | 2019-02-07 | — | — | US | disclosed |
| EP-3380464-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB Biopharma SPRL (BE) | 2018-10-03 | — | — | EP | disclosed |
| WO-2017089453-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2017-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283416-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | PEPD, ADAM17, ANPEP | ALDH1A1 3365/4885TLR8 2145/4885CA1 3579/4885 |
| US-10464932-B2 | Iminothiadiazinane dioxide derivatives as plasmepsin V inhibitors | PEPD, CTSL, SERPINE1 | ALDH1A1 2865/4885TLR8 1268/4885CA1 3291/4885 |
| US-11136310-B2 | Iminotetrahydropyrimidinone derivatives as plasmepsin V inhibitors | PEPD, ADAM17, ANPEP | ALDH1A1 3365/4885TLR8 2145/4885CA1 3579/4885 |
| US-20190040053-A1 | Iminothiadiazinane Dioxide Derivatives as Plasmepsin V Inhibitors | PEPD, CTSL, SERPINE1 | ALDH1A1 2865/4885TLR8 1268/4885CA1 3291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.