Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 4/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15004563 | 0.86 | SMPD1 (0.67) | SMPD1GABRA5PTGESSMN1; SMN2HPGD | |
| SCHEMBL630644 | 0.85 | SMPD1 (0.61) | SMPD1GABRA5PTGESSMN1; SMN2ALDH1A1 | |
| SCHEMBL20152035 | 0.84 | SMPD1 (0.64) | SMPD1GABRA5SMN1; SMN2BRD4 | |
| SCHEMBL2673342 | 0.83 | GABRA5 (0.71) | GABRA5 | |
| SCHEMBL10521252 | 0.82 | SMPD1 (0.60) | SMPD1GABRA5PTGESSMN1; SMN2ALDH1A1 | |
| SCHEMBL630848 | 0.82 | SMPD1 (0.63) | SMPD1PTGES | |
| SCHEMBL10519525 | 0.79 | SMPD1 (0.60) | SMPD1GABRA5PTGESALDH1A1 | |
| SCHEMBL30599028 | 0.79 | SMPD1 (0.51) | SMPD1GABRA5SMN1; SMN2HPGDACACB | |
| SCHEMBL28789794 | 0.78 | SMPD1 (1.00) | SMPD1MME | |
| SCHEMBL10157720 | 0.78 | SMPD1 (0.59) | SMPD1GABRA5PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663466-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |