Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH5 | P11766 | 1/20 | 0.60 |
| ▸ | RPA1 | P27694 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | XDH | P47989 | 11/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984638 | 0.79 | ADH5 (0.95) | ADH5RPA1ATMXDHTP53 | |
| SCHEMBL14381411 | 0.77 | ADH5 (0.67) | ADH5RPA1ATMXDHTP53 | |
| SCHEMBL16144653 | 0.77 | ADH5 (0.67) | ADH5RPA1ATMXDHTP53 | |
| Hydrochloric Acid SCHEMBL21774251 | 0.75 | ADH5 (0.64) | ADH5RPA1ATMXDHTP53 | |
| SCHEMBL6224094 | 0.74 | TP53 (0.64) | ADH5RPA1ATMXDHTP53 | |
| SCHEMBL2645809 | 0.74 | ADH5 (0.75) | ADH5RPA1ATMXDHTP53 | |
| SCHEMBL15004536 | 0.73 | MAPT (0.69) | ADH5XDHTP53GPR35ALDH1A1 | |
| Andolast SCHEMBL1649635 | 0.73 | XDH (0.86) | ADH5XDHGPR35SLC22A12 | |
| SCHEMBL6930170 | 0.73 | XDH (0.63) | ADH5RPA1ATMXDHGPR35 | |
| SCHEMBL23029740 | 0.73 | ADH5 (0.67) | ADH5RPA1ATMXDHTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663466-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |