Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH5 | P11766 | 1/20 | 0.67 |
| ▸ | RPA1 | P27694 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | XDH | P47989 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984638 | 0.83 | ADH5 (0.95) | ADH5RPA1ATMTP53NPC1 | |
| SCHEMBL14381411 | 0.81 | ADH5 (0.67) | ADH5RPA1ATMTP53NPC1 | |
| SCHEMBL19558166 | 0.80 | XDH (0.60) | ADH5RPA1ATMTP53NPC1 | |
| SCHEMBL2667739 | 0.78 | ADH5 (0.75) | ADH5RPA1ATMTP53NPC1 | |
| SCHEMBL15004536 | 0.78 | MAPT (0.69) | ADH5TP53XDHALDH1A1GPR35 | |
| SCHEMBL18896243 | 0.77 | ADH5 (0.60) | ADH5RPA1ATMTP53NPC1 | |
| SCHEMBL762116 | 0.76 | ADH5 (0.79) | ADH5RPA1ATMTP53NPC1 | |
| SCHEMBL15000416 | 0.74 | XDH (0.63) | ADH5TP53NPC1RAB9ANPSR1 | |
| SCHEMBL16326388 | 0.74 | TP53 (0.58) | ADH5RPA1ATMTP53NPC1 | |
| SCHEMBL13113120 | 0.74 | XDH (0.62) | ADH5TP53NPC1RAB9AXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
| WO-2014160592-A2 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046581-A1 | Factor XIa Inhibitors | F11, F12, TFPI | ADH5 4528/4885RPA1 2644/4885ATM 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.