Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12835952 | 0.85 | RAB9A (0.54) | KCNMA1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL23936583 | 0.82 | KCNMA1 (0.51) | KCNMA1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL3906689 | 0.80 | KCNMA1 (0.63) | KCNMA1RAB9AKMT2AMAPTLMNA | |
| SCHEMBL24743260 | 0.78 | RAB9A (0.57) | KCNMA1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL80393 | 0.74 | KCNMA1 (1.00) | KCNMA1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL14253674 | 0.74 | KCNMA1 (0.55) | KCNMA1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL16796215 | 0.73 | RAB9A (0.68) | KCNMA1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL17570759 | 0.72 | KCNMA1 (0.61) | KCNMA1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL15693720 | 0.71 | KCNMA1 (0.60) | KCNMA1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL10429585 | 0.71 | KCNMA1 (0.55) | KCNMA1RAB9AKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651899-B1 | SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2017-05-31 | — | — | EP | disclosed |