Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24016771 | 0.77 | RAB9A (0.53) | KCNMA1RAB9AALDH1A1LMNAMAPK1 | |
| SCHEMBL80393 | 0.76 | KCNMA1 (1.00) | KCNMA1RAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL16796215 | 0.75 | RAB9A (0.68) | KCNMA1RAB9AALDH1A1LMNAMAPK1 | |
| SCHEMBL3163648 | 0.75 | ALDH1A1 (0.61) | RAB9AALDH1A1LMNAMAPTPOLB | |
| SCHEMBL678640 | 0.73 | RAB9A (1.00) | KCNMA1RAB9AALDH1A1LMNAMAPK1 | |
| SCHEMBL30355239 | 0.73 | RAB9A (1.00) | KCNMA1RAB9AALDH1A1LMNAMAPK1 | |
| SCHEMBL3969778 | 0.72 | KCNMA1 (0.78) | KCNMA1RAB9AALDH1A1LMNAMAPK1 | |
| SCHEMBL18899460 | 0.72 | KCNMA1 (0.58) | KCNMA1RAB9ABRD4ALDH1A1LMNA | |
| SCHEMBL24743260 | 0.71 | RAB9A (0.57) | KCNMA1RAB9AALDH1A1LMNAMAPK1 | |
| SCHEMBL11853749 | 0.71 | KCNMA1 (0.61) | KCNMA1RAB9ABRD4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976849-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |