Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.55 |
| ▸ | CFD | P00746 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790223 | 0.84 | ROCK2 (0.53) | ROCK2ROCK1NR1H4KMT2ARAB9A | |
| SCHEMBL18901384 | 0.82 | ROCK2 (0.51) | ROCK2ROCK1NR1H4KMT2ARAB9A | |
| SCHEMBL14081049 | 0.81 | LOXL2 (0.61) | LOXL2CFDHTR2CKMT2ARAB9A | |
| SCHEMBL19634723 | 0.81 | LOXL2 (0.50) | LOXL2CFDHTR2CNR1H4KMT2A | |
| SCHEMBL17788673 | 0.81 | ROCK2 (0.50) | ROCK2ROCK1NR1H4KMT2AGAA | |
| SCHEMBL12331017 | 0.80 | HDAC8 (0.57) | KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL19634726 | 0.79 | LOXL2 (0.63) | LOXL2CFDHTR2CKMT2ARAB9A | |
| SCHEMBL18362111 | 0.78 | LOXL2 (0.49) | LOXL2ROCK2ROCK1KMT2ARAB9A | |
| SCHEMBL6388386 | 0.78 | LOXL2 (0.65) | LOXL2CFDHTR2CRAB9ALOX | |
| SCHEMBL21590340 | 0.77 | PRSS1 (0.65) | KMT2ARAB9ANAMPTGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |