Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790223 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1NR1H4MMP13LMNA | |
| SCHEMBL17788673 | 0.83 | ROCK2 (0.50) | ROCK2ROCK1NR1H4MMP13PPARG | |
| SCHEMBL18901404 | 0.82 | LOXL2 (0.55) | ROCK2ROCK1NR1H4MMP13MEN1 | |
| SCHEMBL16355830 | 0.78 | SLC7A5 (0.56) | NR1H4SMN1; SMN2 | |
| SCHEMBL12331017 | 0.77 | HDAC8 (0.57) | LMNAHDAC8HDAC6MEN1RAB9A | |
| SCHEMBL16366609 | 0.76 | MEP1B (0.65) | NR1H4SMN1; SMN2 | |
| SCHEMBL6906260 | 0.76 | MEP1B (0.49) | LMNAHPGDHDAC2HDAC8HDAC6 | |
| SCHEMBL30444148 | 0.76 | MEP1B (0.65) | NR1H4SMN1; SMN2 | |
| SCHEMBL14234253 | 0.76 | KAT6A (0.52) | ROCK2NR1H4PPARGHDAC2HDAC8 | |
| SCHEMBL19818456 | 0.76 | KAT6A (0.50) | NR1H4MMP13HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |