Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | LCAT | P04180 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18544729 | 0.78 | MAP4K4 (0.50) | CCR2PARP1LCATLMNASMN1; SMN2 | |
| SCHEMBL27726196 | 0.76 | PARP1 (0.50) | CCR2KCNH2PARP1ACACBLCAT | |
| SCHEMBL16648636 | 0.73 | ITGB2 (0.47) | CCR2PARP1ACACBLRRK2LCAT | |
| SCHEMBL2277568 | 0.72 | LCAT (0.45) | CCR2KCNH2PARP1ACACBLCAT | |
| SCHEMBL12969007 | 0.71 | GPR119 (0.54) | PARP1LMNASMN1; SMN2MAPTCKS1B | |
| Hydrochloric Acid SCHEMBL3331239 | 0.70 | HRH3 (0.52) | CCR2KCNH2ACACBHRH3CCR5 | |
| SCHEMBL2277215 | 0.70 | CKS1B (0.53) | CCR2KCNH2ACACBLCATCKS1B | |
| SCHEMBL12968847 | 0.69 | CYP1A2 (0.57) | SMN1; SMN2HRH3MAPTHRH4 | |
| SCHEMBL19658786 | 0.69 | TAF1 (0.51) | CCR2KCNH2PARP1ACACBLCAT | |
| SCHEMBL31706492 | 0.69 | MTNR1B (0.49) | LRRK2LMNAMTNR1BTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |