SCHEMBL18905445

SCHEMBL18905445

[SiH3]CCc1ccc(C2=CCCC2)cc1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ACMSD Q8TDX5 2/20 0.39
HRH3 Q9Y5N1 2/20 0.39
KCNH2 Q12809 1/20 0.39
PTGS2 P35354 1/20 0.33
HDAC2 Q92769 8/20 0.33
HDAC1 Q13547 7/20 0.33
HDAC3 O15379 4/20 0.33
FFAR4 Q5NUL3 1/20 0.32
PSMB5 P28074 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18905499 0.96 ACMSD (0.41) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL18905411 0.89 HRH3 (0.40) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL18905430 0.85 ACMSD (0.40) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL625953 0.77 MAOB (0.46) ACMSDKMT2A
SCHEMBL18905447 0.77 KCNH2 (0.39) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL10793933 0.76 ACMSD (0.53) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL10829186 0.76 HSD11B1 (0.43) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL18905437 0.73 ACMSD (0.39) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL18905536 0.73 ACMSD (0.44) ACMSDHRH3KCNH2PTGS2HDAC2
SCHEMBL8885877 0.72 ACMSD (0.44) ACMSDHRH3KCNH2PTGS2HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170154766-A1 SILICON-CONTAINING CONDENSATE, COMPOSITION FOR FORMING A SILICON-CONTAINING RESIST UNDER LAYER FILM, AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2017-06-01 US disclosed