Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083789 | 0.86 | ALDH1A1 (0.48) | ACHEBCHEBACE1ALDH1A1TSHR | |
| SCHEMBL19075549 | 0.84 | ALDH1A1 (0.46) | ACHEBCHEBACE1ALDH1A1TSHR | |
| SCHEMBL18908933 | 0.82 | ACHE (0.45) | ACHEBCHEBACE1ALDH1A1TSHR | |
| SCHEMBL18908857 | 0.80 | ALDH1A1 (0.43) | ACHEBCHEBACE1ALDH1A1TSHR | |
| SCHEMBL23762530 | 0.77 | ALDH1A1 (0.41) | ACHEBCHEBACE1ALDH1A1TSHR | |
| SCHEMBL19084054 | 0.73 | ACHE (0.45) | ACHEBCHEBACE1ALDH1A1TSHR | |
| SCHEMBL25541744 | 0.73 | TSHR (0.48) | ACHEBCHEBACE1ALDH1A1TSHR | |
| SCHEMBL17423059 | 0.73 | SCN7A (0.53) | — | |
| SCHEMBL8218177 | 0.73 | GRIN2B (0.43) | ALDH1A1TSHR | |
| SCHEMBL28195942 | 0.73 | GRIN2B (0.43) | CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017091592-A1 | SUBSTITUTED BENZAMIDES USEFUL AS SODIUM CHANNEL BLOCKERS | GENENTECH, INC. (US) | 2017-06-01 | — | — | WO | disclosed |