Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22891320 | 1.00 | PKM (0.41) | PKMEPHX2KDM2BKDM4EL3MBTL1 | |
| SCHEMBL21281054 | 1.00 | PKM (0.41) | PKMEPHX2KDM2BKDM4EL3MBTL1 | |
| SCHEMBL18909248 | 0.92 | KDM2B (0.42) | PKMEPHX2KDM2BKDM4EL3MBTL1 | |
| SCHEMBL24244806 | 0.86 | MEN1 (0.40) | PKMKDM2BKDM4EL3MBTL1MEN1 | |
| SCHEMBL21281022 | 0.86 | MEN1 (0.40) | PKMKDM2BKDM4EL3MBTL1MEN1 | |
| SCHEMBL24521475 | 0.86 | SMN1; SMN2 (0.43) | PKMEPHX2KDM4EL3MBTL1MEN1 | |
| SCHEMBL22891321 | 0.85 | DPP4 (0.41) | PKMKDM2BKDM4EL3MBTL1MEN1 | |
| SCHEMBL26148283 | 0.85 | KDM4E (0.47) | PKMKDM2BKDM4EL3MBTL1MEN1 | |
| SCHEMBL26148290 | 0.85 | DPP4 (0.41) | PKMKDM2BKDM4EL3MBTL1MEN1 | |
| SCHEMBL24584617 | 0.84 | MEN1 (0.37) | PKMKDM2BKDM4EL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017140825-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017089390-A1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-01 | — | — | WO | disclosed |