Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18909103 | 0.92 | PKM (0.41) | KDM2BCHRM1EPHX2ALDH1A1PKM | |
| SCHEMBL22891320 | 0.92 | PKM (0.41) | KDM2BCHRM1EPHX2ALDH1A1PKM | |
| SCHEMBL21281054 | 0.92 | PKM (0.41) | KDM2BCHRM1EPHX2ALDH1A1PKM | |
| SCHEMBL23514580 | 0.91 | CHRM1 (0.44) | KDM2BCHRM1EPHX2CHRM2ALDH1A1 | |
| SCHEMBL22891271 | 0.85 | DPP4 (0.42) | KDM2BCHRM1 | |
| SCHEMBL16621798 | 0.84 | CHRNB2 (0.42) | EPHX2ALDH1A1EPHX1JAK2JAK1 | |
| SCHEMBL13045920 | 0.84 | EPHX2 (0.47) | EPHX2ALDH1A1EPHX1CHRNB2CHRNA3 | |
| SCHEMBL24585220 | 0.79 | MGLL (0.39) | KDM2BCHRM1EPHX2ALDH1A1KDM4E | |
| SCHEMBL24585219 | 0.79 | MGLL (0.39) | KDM2BCHRM1EPHX2ALDH1A1KDM4E | |
| SCHEMBL24521475 | 0.77 | SMN1; SMN2 (0.43) | CHRM1EPHX2CHRM2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017089390-A1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-01 | — | — | WO | disclosed |