Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24244805 | 1.00 | EPHX2 (0.40) | EPHX2MCHR1NPY5RKMT2AALDH1A1 | |
| SCHEMBL18909095 | 0.91 | EPHX2 (0.42) | EPHX2NPY5RKMT2AALDH1A1LMNA | |
| SCHEMBL22030901 | 0.84 | CYP3A4 (0.39) | MCHR1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22030318 | 0.84 | CYP3A4 (0.39) | MCHR1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL21280987 | 0.84 | KMT2A (0.41) | MCHR1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16509333 | 0.78 | ALDH1A1 (0.42) | EPHX2MCHR1NPY5RALDH1A1 | |
| SCHEMBL4489462 | 0.77 | MCHR1 (0.43) | MCHR1KMT2A | |
| SCHEMBL24521409 | 0.77 | CPN1 (0.40) | MCHR1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19259598 | 0.77 | KMT2A (0.37) | MCHR1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12516865 | 0.77 | L3MBTL3 (0.53) | EPHX2NPY5RALDH1A1EPHX1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |
| EP-3416967-B1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-02-09 | — | — | EP | disclosed |
| EP-3380474-B1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-08-21 | — | — | EP | disclosed |
| WO-2017140825-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017089390-A1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-01 | — | — | WO | disclosed |