Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21281128 | 0.97 | EPHX2 (0.49) | EPHX2MEN1KMT2ASMN1; SMN2NPY5R | |
| SCHEMBL19444608 | 0.86 | KMT2A (0.47) | EPHX2MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL19444620 | 0.86 | KMT2A (0.47) | EPHX2MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL24521422 | 0.86 | CPN1 (0.40) | EPHX2MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL18909251 | 0.84 | EPHX2 (0.45) | EPHX2MEN1KMT2ASMN1; SMN2NPY5R | |
| SCHEMBL30098883 | 0.84 | LMNA (0.41) | MEN1KMT2ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL22030873 | 0.83 | CYP3A4 (0.41) | MEN1KMT2ASMN1; SMN2ATMALDH1A1 | |
| SCHEMBL24521472 | 0.83 | KMT2A (0.40) | EPHX2MEN1KMT2ASMN1; SMN2ATM | |
| SCHEMBL24244796 | 0.83 | CPN1 (0.40) | EPHX2MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16604741 | 0.82 | ALDH1A1 (0.43) | MEN1KMT2ASMN1; SMN2L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |
| EP-3416967-B1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-02-09 | — | — | EP | disclosed |
| EP-3380474-B1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-08-21 | — | — | EP | disclosed |
| WO-2017140825-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017089390-A1 | JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-01 | — | — | WO | disclosed |