SCHEMBL18909892

SCHEMBL18909892

CCCCOCCN1CCC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.51
HRH3 Q9Y5N1 5/20 0.43
MAPK1 P28482 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
CHRM2 P08172 1/20 0.43
CHRM1 P11229 1/20 0.43
HTR2A P28223 1/20 0.43
SCN1A P35498 1/20 0.43
HTR2B P41595 1/20 0.43
KCNH2 Q12809 1/20 0.43
SCN2A Q99250 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
SCN3A Q9NY46 1/20 0.43
TSHR P16473 1/20 0.43
USP2 O75604 1/20 0.42
LMNA P02545 1/20 0.42
KDM4E B2RXH2 1/20 0.41
HTT P42858 1/20 0.41
GNAI3 P08754 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3306544 0.96 LTA4H (0.56) LTA4HHRH3MAPK1ALDH1A1CYP1A2
SCHEMBL3303079 0.94 LTA4H (0.54) LTA4HHRH3ALDH1A1CYP1A2CHRM2
SCHEMBL3308012 0.94 LTA4H (0.54) LTA4HHRH3MAPK1ALDH1A1CYP1A2
SCHEMBL501405 0.94 LTA4H (0.54) LTA4HHRH3MAPK1ALDH1A1CYP1A2
SCHEMBL3303986 0.92 LTA4H (0.53) LTA4HHRH3ALDH1A1CYP1A2CHRM2
SCHEMBL955788 0.92 LTA4H (0.53) LTA4HHRH3ALDH1A1CYP1A2CHRM2
SCHEMBL24757676 0.91 LTA4H (0.51) LTA4HHRH3MAPK1ALDH1A1CYP1A2
SCHEMBL19559067 0.91 GNAI3 (0.47) LTA4HHRH3MAPK1ALDH1A1CYP1A2
SCHEMBL3307768 0.89 LTA4H (0.59) LTA4HHRH3ALDH1A1CHRM2KCNH2
SCHEMBL15510652 0.89 HRH3 (0.53) LTA4HHRH3CHRM2KCNH2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017091602-A1 ESTER ACC INHIBITORS AND USES THEREOF GILEAD APOLLO, LLC (US) 2017-06-01 WO disclosed