Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15831849 | 0.84 | PRKDC (0.47) | ALDH1A1PRKDCL3MBTL1P2RX7LMNA | |
| SCHEMBL5337316 | 0.81 | HTR1A (0.51) | CYP3A4CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL5793530 | 0.79 | NCF1 (0.45) | ALDH1A1PRKDCLMNASMN1; SMN2HPGD | |
| SCHEMBL19212319 | 0.78 | MAPT (0.53) | ALDH1A1PRKDCL3MBTL1AKR1C3P2RX7 | |
| SCHEMBL3885064 | 0.78 | KMT2A (0.53) | ALDH1A1PRKDCL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL16577085 | 0.77 | HTR1A (0.45) | PRKDCP2RX7LMNACYP2C9CYP1A2 | |
| SCHEMBL1715455 | 0.76 | AKR1C3 (0.50) | ALDH1A1PRKDCL3MBTL1AKR1C3P2RX7 | |
| SCHEMBL12864867 | 0.76 | MAPT (0.64) | ALDH1A1PRKDCL3MBTL1AKR1C3P2RX7 | |
| SCHEMBL23168991 | 0.76 | PRKDC (0.43) | ALDH1A1PRKDCL3MBTL1P2RX7LMNA | |
| SCHEMBL18914549 | 0.76 | PRKDC (0.43) | ALDH1A1PRKDCL3MBTL1P2RX7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3381913-B1 | 2-(((PYRROLIDIN-3-YL)CARBONYL)AMINO)-1H-IMIDAZOLE DERIVATIVES AS MELANOCORTIN RECEPTOR 1 (MCR1) AGONISTS FOR TREATING RHEUMATOID ARTHRITIS | MITSUBISHI TANABE PHARMA CORP (JP) | 2021-03-31 | — | — | EP | disclosed |
| WO-2017090743-A1 | NOVEL IMIDAZOLE COMPOUND AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONIST | 田辺三菱製薬株式会社 | 2017-06-01 | — | — | WO | disclosed |