Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | DRD5 | P21918 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194645 | 0.85 | ALOX15 (0.68) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL1527730 | 0.82 | HIF1A (0.40) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL107956 | 0.79 | ALOX15 (0.80) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL30631592 | 0.79 | ALOX15 (0.80) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL469713 | 0.79 | ALOX15 (0.59) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL3217327 | 0.78 | CA1 (0.56) | ALOX15IGF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL6899643 | 0.78 | SERPINE1 (0.38) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL910429 | 0.78 | TAAR1 (0.65) | ALDH1A1GAAALOX5MAPK1TDP1 | |
| SCHEMBL909945 | 0.78 | CYP3A4 (0.63) | ALOX15GAAADRB2APEX1LMNA | |
| SCHEMBL8431254 | 0.77 | ALOX15 (0.76) | ALOX15IGF1RMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787484-B2 | Compositions and methods for treating cardiovascular disease | GENENTECH, INC. (US) | 2020-09-29 | — | — | US | claimed |
| US-20190177366-A1 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASE | GENENTECH, INC. (US) | 2019-06-13 | — | — | US | claimed |
| US-20090300800-A1 | D-Amino Acid a Selectable Marker for Barley (Hordeum Vulgare L.) Transformation | BASF PLANT SCIENCE GMBH (DE) | 2009-12-03 | — | — | US | claimed |
| US-20070248996-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | PARAECIS PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | US | claimed |
| US-20060014696-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | PRAECIS PHARMACEUTICALS, INC. (US) | 2006-01-19 | — | — | US | claimed |
| EP-0929574-B1 | MODULATORS OF beta-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS | PRAECIS PHARM INC (US) | 2005-06-29 | — | — | EP | claimed |
| US-20020103134-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | PRAECIS PHARMACEUTICALS INC. | 2002-08-01 | — | — | US | claimed |
| US-5985242-A | PEPTIDE OF 3 TO 5 D-AMINO ACIDS; MAY BE MODIFIED AT AMINO-AND/OR CARBOXY TERMINUS; FOR TREATMENT OF AMYLOIDOSIS, ALZHEIMER'S DISEASE | PRAECIS PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | claimed |
| US-5502036-A | VIRICIDES | BIOMEGA BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1996-03-26 | — | — | US | claimed |
| EP-0411332-B1 | Antiviral peptides having a 2-oxoalkyl amino acid side chain | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1995-12-06 | — | — | EP | claimed |
| EP-0411334-B1 | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1995-02-22 | — | — | EP | claimed |
| EP-0411334-A1 | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1991-02-06 | — | — | EP | claimed |
| US-20240229088-A1 | POLYAMINE ANALOG PRODUCING YEASTS | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2024-07-11 | — | — | US | disclosed |
| CN-115820757-B | Application of coding gene and protein of wolfberry BAHD (binary high definition) acyltransferase | 中国科学院华南植物园 | 2023-06-20 | — | — | CN | disclosed |
| CN-115820757-B | Application of coding gene and protein of wolfberry BAHD (binary high definition) acyltransferase | 中国科学院华南植物园 | 2023-06-20 | — | — | CN | disclosed |
| CN-115820577-B | Medlar 4-coumaric acid: encoding gene of coenzyme A ligase and application of protein | 中国科学院华南植物园 | 2023-06-20 | — | — | CN | disclosed |
| EP-0411332-B1 | Antiviral peptides having a 2-oxoalkyl amino acid side chain | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1995-12-06 | — | — | EP | disclosed |
| EP-0411334-B1 | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1995-02-22 | — | — | EP | disclosed |
| EP-0508234-A2 | Beta-lactames | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-14 | — | — | EP | disclosed |
| EP-0411332-A1 | Antiviral peptides having a 2-oxoalkyl amino acid side chain | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1991-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070248996-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | APP, IAPP, BACE1 | ALOX15 580/4885IGF1R 268/4885MAPT 121/4885 |
| US-20020103134-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | IAPP, APP, VIP | ALOX15 554/4885IGF1R 795/4885MAPT 297/4885 |
| US-20060014696-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | APP, IAPP, BACE1 | ALOX15 580/4885IGF1R 268/4885MAPT 121/4885 |
| US-10787484-B2 | Compositions and methods for treating cardiovascular disease | PCSK9, PCSK7, PCSK6 | ALOX15 346/4885IGF1R 3025/4885MAPT 1767/4885 |
| US-20190177366-A1 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASE | PCSK9, PCSK7, PCSK6 | ALOX15 346/4885IGF1R 3025/4885MAPT 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.