Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.38 |
| ▸ | SELL | P14151 | 5/20 | 0.36 |
| ▸ | SELP | P16109 | 5/20 | 0.36 |
| ▸ | SELE | P16581 | 4/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | SNCA | P37840 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | FUT4 | P22083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10787148 | 0.78 | TTR (0.41) | MAPTALDH1A1LMNAHSD17B10HTT | |
| SCHEMBL1891731 | 0.78 | ALOX15 (0.59) | ADRB2KDM4EMAPTTDP1MAPK1 | |
| SCHEMBL6900178 | 0.78 | KDM4E (0.39) | SERPINE1SELLSELPSELEKDM4E | |
| SCHEMBL265388 | 0.74 | GAA (0.53) | KDM4EMAPTTDP1MAPK1ALDH1A1 | |
| SCHEMBL4846564 | 0.73 | CES2 (0.34) | — | |
| SCHEMBL1009733 | 0.71 | EGFR (0.43) | MAPTTDP1MAPK1TP53HPGD | |
| SCHEMBL17138365 | 0.70 | TDP1 (0.62) | ADRB2KDM4EMAPTTDP1MAPK1 | |
| SCHEMBL328576 | 0.70 | TDP1 (0.62) | ADRB2KDM4EMAPTTDP1MAPK1 | |
| 3,4,5-Trihydroxyphenethyl Alcohol SCHEMBL2990691 | 0.70 | KDM4E (0.58) | SERPINE1SELLSELPSELEADRB2 | |
| SCHEMBL909945 | 0.70 | CYP3A4 (0.63) | ADRB2LMNAAPEX1GAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171130-A4 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARM INC (US) | 2004-05-19 | — | — | EP | claimed |
| US-20030078212-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. | 2003-04-24 | — | — | US | claimed |
| JP-2002540060-A | — | — | 2002-11-26 | — | — | JP | claimed |
| EP-1171130-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2002-01-16 | — | — | EP | claimed |
| WO-2000025787-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2000-05-11 | — | — | WO | claimed |
| EP-1171130-A4 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARM INC (US) | 2004-05-19 | — | — | EP | disclosed |
| US-20030078212-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. | 2003-04-24 | — | — | US | disclosed |
| EP-1171130-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000025787-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | GUILFORD PHARMACEUTICALS INC. (US) | 2000-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078212-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS AND METHODS OF USING THE SAME | PARP10, PARG, DERA | SERPINE1 84/4885SELL 1184/4885SELP 1874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.