Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | THRA | P10827 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11454899 | 1.00 | THRB (0.48) | THRBTHRAPPARASPHK2SPHK1 | |
| SCHEMBL18920727 | 0.84 | NR5A1 (0.49) | LMNATP53HSD17B10 | |
| SCHEMBL18920616 | 0.80 | PPARA (0.44) | THRBTHRAPPARAESR1ADRA2A | |
| SCHEMBL26939981 | 0.78 | ESR1 (0.53) | THRBTHRAPPARASPHK1ESR1 | |
| SCHEMBL19058769 | 0.78 | ESR1 (0.53) | THRBTHRAPPARASPHK1ESR1 | |
| SCHEMBL8734047 | 0.78 | ESR1 (0.53) | THRBTHRAPPARASPHK1ESR1 | |
| SCHEMBL10896930 | 0.76 | THRB (0.52) | THRBTHRASPHK2SPHK1ESR1 | |
| SCHEMBL10411867 | 0.75 | THRA (0.49) | THRBTHRASPHK2SPHK1ESR1 | |
| SCHEMBL7871491 | 0.75 | THRA (0.49) | THRBTHRASPHK2SPHK1ESR1 | |
| SCHEMBL27082092 | 0.75 | THRA (0.49) | THRBTHRASPHK2SPHK1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017093351-A1 | CPLA2 INHIBITORS | Westfälische Wilhelms-Universität Münster (DE) | 2017-06-08 | — | — | WO | disclosed |