Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877403 | 0.77 | GRIN1 (0.42) | MMP3PIK3CGFLT3LMNAMAPT | |
| SCHEMBL12965933 | 0.73 | CHEK1 (0.44) | MMP3PIK3CDPIK3CAMTORCYP11B2 | |
| SCHEMBL4006124 | 0.68 | MMP3 (0.72) | MMP3PIK3CGPIK3CDPIK3CAMTOR | |
| SCHEMBL30504282 | 0.68 | MMP3 (0.79) | MMP3PIK3CGPIK3CDPIK3CAMTOR | |
| SCHEMBL4001097 | 0.66 | MMP3 (0.82) | MMP3PIK3CGPIK3CACYP11B2TGFBR1 | |
| SCHEMBL4009763 | 0.66 | MMP3 (0.82) | MMP3PIK3CGPIK3CACYP11B2TGFBR1 | |
| SCHEMBL8338095 | 0.66 | MMP3 (0.70) | MMP3PIK3CGPIK3CDPIK3CAMTOR | |
| SCHEMBL5580517 | 0.65 | MMP3 (0.51) | MMP3PIK3CGPIK3CDPIK3CAMTOR | |
| SCHEMBL338712 | 0.65 | MMP3 (0.73) | MMP3PIK3CGPIK3CAFLT3LMNA | |
| SCHEMBL20122537 | 0.64 | GRIN1 (0.42) | GSK3BCDK2LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962382-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-05-08 | — | — | US | disclosed |
| US-9669028-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2017-06-06 | — | — | US | disclosed |