Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.49 |
| ▸ | NOS3 | P29474 | 4/20 | 0.49 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.34 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.33 |
| ▸ | GABRE | P78334 | 2/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18922136 | 0.90 | NOS3 (0.55) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL18431456 | 0.83 | NOS2 (0.52) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL22623994 | 0.81 | UHRF1 (0.39) | PRKCQESR1ESR2DYRK1AAR | |
| SCHEMBL18879382 | 0.80 | NOS3 (0.57) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL23561212 | 0.80 | ESR1 (0.39) | PRKCQESR1ESR2AR | |
| SCHEMBL21419175 | 0.78 | LOXL2 (0.42) | NOS2NOS3PRKCQAR | |
| SCHEMBL21099739 | 0.78 | LOX (0.42) | PRKCQESR1ESR2DYRK1AAR | |
| SCHEMBL18505948 | 0.78 | AR (0.33) | PRKCQGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL18948856 | 0.76 | CYP3A4 (0.31) | PRKCQESR1ESR2AR | |
| SCHEMBL18948721 | 0.76 | PRKCQ (0.32) | PRKCQESR1ESR2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670231-B2 | Fused tricyclic amide compounds as multiple kinase inhibitors | BEIGENE, LTD. (KY) | 2017-06-06 | — | — | US | disclosed |