Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA3 | P07451 | 3/20 | 0.45 |
| ▸ | CA4 | P22748 | 3/20 | 0.45 |
| ▸ | CA6 | P23280 | 3/20 | 0.45 |
| ▸ | CA5A | P35218 | 3/20 | 0.45 |
| ▸ | CA7 | P43166 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5179114 | 0.78 | APP (0.94) | APPKDM4EALDH1A1MAPTMAOB | |
| SCHEMBL11439096 | 0.78 | APP (0.94) | APPKDM4EALDH1A1MAPTMAOB | |
| SCHEMBL9790648 | 0.77 | MAOB (0.59) | ALDH1A1MAPTMAOBLMNANPC1 | |
| SCHEMBL144447 | 0.77 | MAOB (0.59) | ALDH1A1MAPTMAOBLMNANPC1 | |
| SCHEMBL10421204 | 0.77 | APP (0.54) | APPKDM4EALDH1A1MAPTMAOB | |
| SCHEMBL3526329 | 0.77 | APP (0.54) | APPKDM4EALDH1A1MAPTMAOB | |
| SCHEMBL21798645 | 0.76 | APP (1.00) | APPKDM4EALDH1A1MAPTMAOB | |
| SCHEMBL2829008 | 0.76 | APP (1.00) | APPKDM4EALDH1A1MAPTMAOB | |
| Hydrochloric Acid SCHEMBL11478395 | 0.76 | APP (0.52) | APPKDM4EALDH1A1MAPTMAOB | |
| Hydrochloric Acid SCHEMBL11478399 | 0.76 | APP (0.52) | APPKDM4EALDH1A1MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935728-B1 | Cyclic palladium compounds having coordinated thereto bis (diphenylphosphine) ferrocene ligands which inhibit the activity of proteins and enzymes and treatment of diseases and disorders associated therewith | FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO (BR) | 2011-05-03 | — | — | US | disclosed |
| EP-1534257-B1 | CYCLIC PALLADIUM COMPOUNDS HAVING COORDINATED THERETO BIS (DIPHENYLPHOSPHINE) FERROCENE LIGANDS WHICH INHIBIT THE ACTIVITY OF PROTEINS AND ENZYMES AND TREATMENT OF DISEASES AND DISORDERS ASSOCIATED THEREWITH. | FUNDACAO DE AMPARO A PESQUISA (BR) | 2010-10-20 | — | — | EP | disclosed |
| US-7432403-B2 | Cyclic palladium compounds having coordinated thereto bis (diphenylphosphine) ferrocene ligands which inhibit the activity of proteins and enzymes and treatment of diseases and disorders associated therewith | Fundação De Amparo À Pesquisa Do Estado de São Paulo (BR) | 2008-10-07 | — | — | US | disclosed |
| US-20060106100-A1 | Cyclic palladium compounds having coordinated thereto bis (diphenylphosphine) ferrocene ligands which inhibit the activity of proteins and enzymes and treatment of diseases and disorders associated therewith | FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO (BR) | 2006-05-18 | — | — | US | disclosed |
| EP-1534257-A1 | CYCLIC PALLADIUM COMPOUNDS HAVING COORDINATED THERETO BIS (DIPHENYLPHOSPHINE) FERROCENE LIGANDS WHICH INHIBIT THE ACTIVITY OF PROTEINS AND ENZYMES AND TREATMENT OF DISEASES AND DISORDERS ASSOCIATED THEREWITH. | Fundacao de Amparo a Pesquisa do Estado de Sao Paolo (BR) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004019924-A1 | CYCLIC PALLADIUM COMPOUNDS HAVING COORDINATED THERETO BIS (DIPHENYLPHOSPHINE) FERROCENE LIGANDS WHICH INHIBIT THE ACTIVITY OF PROTEINS AND ENZYMES AND TREATMENT OF DISEASES AND DISORDERS ASSOCIATED THEREWITH. | FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP (BR) | 2004-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106100-A1 | Cyclic palladium compounds having coordinated thereto bis (diphenylphosphine) ferrocene ligands which inhibit the activity of proteins and enzymes and treatment of diseases and disorders associated therewith | PREP, DNPEP, RNASE1 | APP 1768/4885KDM4E 2380/4885ALDH1A1 3738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.