Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 11/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15440779 | 0.90 | HTR3A (0.54) | HTR3AALDH1A1HTR7NR4A2LMNA | |
| SCHEMBL15444633 | 0.84 | HTR3A (0.56) | HTR3AALDH1A1HTR7NR4A2LMNA | |
| SCHEMBL6044056 | 0.81 | HTR3A (0.53) | HTR3AHTR7NR4A2KDM4EPOLB | |
| SCHEMBL15420930 | 0.79 | NR4A2 (0.64) | HTR3AALDH1A1NR4A2MAPTKDM4E | |
| SCHEMBL20080348 | 0.79 | KMT2A (0.52) | HTR3AALDH1A1HTR7MAPTNPSR1 | |
| SCHEMBL20080410 | 0.78 | HTR3A (0.51) | HTR3AALDH1A1HTR7NR4A2MAPT | |
| SCHEMBL19068191 | 0.78 | HTR3A (0.54) | HTR3AALDH1A1NR4A2 | |
| SCHEMBL17170671 | 0.76 | HTR3A (0.57) | HTR3AALDH1A1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL17170607 | 0.76 | ALDH1A1 (0.53) | HTR3AALDH1A1NR4A2LMNASMN1; SMN2 | |
| SCHEMBL15441066 | 0.75 | HTR3A (0.55) | HTR3AALDH1A1MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670229-B2 | 5-HT3 receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-06-06 | — | — | US | disclosed |