Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4936308 | 0.95 | GAA (0.43) | L3MBTL1LMNAGAADDB1CRBN | |
| SCHEMBL4938895 | 0.88 | LMNA (0.47) | L3MBTL1LMNAGAAKMT2AMEN1 | |
| SCHEMBL4931976 | 0.85 | DDB1 (0.42) | LMNAGAADDB1CRBNKMT2A | |
| SCHEMBL4939139 | 0.85 | SMN1; SMN2 (0.49) | L3MBTL1LMNAGAAKMT2AMEN1 | |
| Niacin SCHEMBL4936302 | 0.84 | DDB1 (0.41) | L3MBTL1LMNAGAADDB1CRBN | |
| SCHEMBL4938878 | 0.81 | GAA (0.43) | L3MBTL1LMNAGAADDB1CRBN | |
| SCHEMBL3593195 | 0.79 | L3MBTL1 (0.45) | L3MBTL1LMNAGAAKMT2AMEN1 | |
| SCHEMBL31623352 | 0.79 | DDB1 (0.48) | GAADDB1CRBNKMT2AMEN1 | |
| SCHEMBL4940932 | 0.79 | DDB1 (0.48) | GAADDB1CRBNKMT2AMEN1 | |
| SCHEMBL19889418 | 0.79 | DDB1 (0.36) | LMNAGAADDB1CRBNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9669015-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2017-06-06 | — | — | US | disclosed |