Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31623352 | 1.00 | DDB1 (0.48) | DDB1CRBNCASP1HSD17B10KMT2A | |
| SCHEMBL4937736 | 0.94 | CRBN (0.50) | DDB1CRBNCASP1HSD17B10KMT2A | |
| SCHEMBL31623335 | 0.94 | CRBN (0.50) | DDB1CRBNCASP1HSD17B10KMT2A | |
| SCHEMBL26996408 | 0.84 | DDB1 (0.52) | DDB1CRBNKMT2AALDH1A1POLB | |
| SCHEMBL4939213 | 0.83 | CRBN (0.47) | DDB1CRBNCASP1HSD17B10KMT2A | |
| SCHEMBL29945628 | 0.83 | ALDH1A1 (0.42) | DDB1CRBNHSD17B10KMT2AMEN1 | |
| SCHEMBL4931124 | 0.83 | CRBN (0.53) | DDB1CRBNCASP1HSD17B10KMT2A | |
| SCHEMBL4939110 | 0.82 | DDB1 (0.49) | DDB1CRBNKMT2AMEN1MAPT | |
| SCHEMBL21402689 | 0.82 | CRBN (0.49) | DDB1CRBNCASP1HSD17B10KMT2A | |
| SCHEMBL14297668 | 0.81 | CRBN (0.44) | DDB1CRBNCASP1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132466-A1 | PIPERIDINE-2,6-DIONE DERIVATIVES AND ULCERATIVE COLITIS TREATING | TIANJIN HEMAY PHARMACEUTICAL SCI TECH CO LTD (CN) | 2024-04-25 | — | — | US | claimed |
| US-10406147-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2019-09-10 | — | — | US | claimed |
| US-20190247383-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2019-08-15 | — | — | US | claimed |
| US-10166222-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2019-01-01 | — | — | US | claimed |
| US-20180050025-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2018-02-22 | — | — | US | claimed |
| US-9669015-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2017-06-06 | — | — | US | claimed |
| US-20150272940-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2015-10-01 | — | — | US | claimed |
| US-20140179737-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-06-26 | — | — | US | claimed |
| US-8637545-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-01-28 | — | — | US | claimed |
| US-12331030-B2 | Piperidine-2,6-dione derivatives and ulcerative colitis treating | TIANJIN HEMAY PHARMACEUTICAL SCI-TECH CO., LTD (CN) | 2025-06-17 | — | — | US | disclosed |
| US-20240132466-A1 | PIPERIDINE-2,6-DIONE DERIVATIVES AND ULCERATIVE COLITIS TREATING | TIANJIN HEMAY PHARMACEUTICAL SCI TECH CO LTD (CN) | 2024-04-25 | — | — | US | disclosed |
| US-11873287-B2 | Piperidine-2,6-dione derivatives and ulcerative colitis treating | TIANJIN HEMAY PHARMACEUTICAL SCI-TECH CO., LTD (CN) | 2024-01-16 | — | — | US | disclosed |
| US-20220372013-A2 | PIPERIDINE-2,6-DIONE DERIVATIVES AND CROHN'S DISEASE TREATING | GANZHOU HEMAY PHARMACEUTICAL, CO., LTD (CN) | 2022-11-24 | — | — | US | disclosed |
| US-11485724-B2 | Piperidine-2,6-dione derivatives and ulcerative colitis treating | TIANJIN HEMAY PHARMACEUTICAL SCI-TECH CO., LTD (CN) | 2022-11-01 | — | — | US | disclosed |
| US-8637545-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-01-28 | — | — | US | disclosed |
| US-8637545-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2014-01-28 | — | — | US | disclosed |
| EP-1867649-B1 | PIPERIDYL-2, 6-DIONE DERIVATIVES USED TO INHIBIT CELLS FROM RELEASING TUMOR NECROSIS FACTOR | TIAN JIN HEMAY BIO TECH CO LTD (CN) | 2012-12-12 | — | — | EP | disclosed |
| US-20080051432-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2008-02-28 | — | — | US | disclosed |
| US-20080051432-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TIANJIN HEMAY PHARMACEUTICAL CO., LTD. (CN) | 2008-02-28 | — | — | US | disclosed |
| EP-1867649-A1 | PIPERIDYL-2, 6-DIONE DERIVATIVES USED TO INHIBIT CELLS FROM RELEASING TUMOR NECROSIS FACTOR | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2007-12-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132466-A1 | PIPERIDINE-2,6-DIONE DERIVATIVES AND ULCERATIVE COLITIS TREATING | DPYD, PTGDR2, UCK2 | DDB1 3183/4885CRBN 3209/4885CASP1 1378/4885 |
| US-20180050025-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNFRSF9, TNFRSF1A, NGFR | DDB1 2855/4885CRBN 949/4885CASP1 587/4885 |
| US-10406147-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TNF, TNFRSF1A, TNFRSF9 | DDB1 2336/4885CRBN 896/4885CASP1 625/4885 |
| US-10166222-B2 | Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors | TNFRSF1A, TNFRSF9, NGFR | DDB1 2770/4885CRBN 1007/4885CASP1 560/4885 |
| US-20150272940-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | DDB1 2336/4885CRBN 896/4885CASP1 625/4885 |
| US-20190247383-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | DDB1 2373/4885CRBN 862/4885CASP1 573/4885 |
| US-12331030-B2 | Piperidine-2,6-dione derivatives and ulcerative colitis treating | DPYD, PTGDR2, UCK2 | DDB1 3183/4885CRBN 3209/4885CASP1 1378/4885 |
| US-11485724-B2 | Piperidine-2,6-dione derivatives and ulcerative colitis treating | DPYD, PTGDR2, UCK2 | DDB1 3183/4885CRBN 3209/4885CASP1 1378/4885 |
| US-20080051432-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | DDB1 2336/4885CRBN 896/4885CASP1 625/4885 |
| US-11873287-B2 | Piperidine-2,6-dione derivatives and ulcerative colitis treating | DPYD, PTGDR2, UCK2 | DDB1 3183/4885CRBN 3209/4885CASP1 1378/4885 |
| US-20220372013-A2 | PIPERIDINE-2,6-DIONE DERIVATIVES AND CROHN'S DISEASE TREATING | PTGDR2, PTGDR, TPMT | DDB1 3702/4885CRBN 3060/4885CASP1 1590/4885 |
| US-20140179737-A1 | PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS | TNF, TNFRSF1A, TNFRSF9 | DDB1 2336/4885CRBN 896/4885CASP1 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.