Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203063 | 0.82 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDLMNAL3MBTL1 | |
| SCHEMBL20877697 | 0.80 | ALDH1A1 (0.36) | KDM4EALDH1A1HPGDLMNAL3MBTL1 | |
| SCHEMBL18745838 | 0.78 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDLMNAGAA | |
| SCHEMBL18924315 | 0.75 | IGF1R (0.42) | KDM4EALDH1A1HPGDLMNAL3MBTL1 | |
| SCHEMBL21652254 | 0.74 | KIF11 (0.47) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL21994156 | 0.72 | MAPT (0.46) | KMT2APOLB | |
| SCHEMBL25847426 | 0.72 | KDM4E (0.51) | KDM4EALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL20197187 | 0.72 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDLMNAHTT | |
| SCHEMBL19863918 | 0.72 | UHRF1 (0.42) | AR | |
| SCHEMBL23879473 | 0.70 | CNR2 (0.38) | ALDH1A1LMNAL3MBTL1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670172-B2 | Heterocyclic compounds and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2017-06-06 | — | — | US | disclosed |