Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19523162 | 0.77 | ADORA1 (0.38) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL14213484 | 0.76 | CYP2A6 (0.33) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7607941 | 0.73 | KDM4E (0.35) | LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL22161609 | 0.73 | CYP2A6 (0.31) | — | |
| SCHEMBL14213485 | 0.73 | HSD17B10 (0.50) | ADORA2AMAPTALDH1A1HSD17B10 | |
| SCHEMBL21341741 | 0.70 | ALDH1A1 (0.31) | ADORA2AADORA1TSHRPRNPRXFP1 | |
| SCHEMBL20691176 | 0.70 | ALDH1A1 (0.36) | ADORA2AADORA1TSHRLMNAMAPT | |
| SCHEMBL18211812 | 0.70 | AURKA (0.32) | ADORA2AADORA1PRNPRXFP1MAPT | |
| SCHEMBL16840458 | 0.70 | NUDT1 (0.39) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL14985883 | 0.69 | GPR3 (0.55) | TSHRNPSR1PRNPRXFP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670196-B2 | Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-06-06 | — | — | US | disclosed |