Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945402 | 0.83 | NPC1 (0.45) | ASH1LCYP2A6CYP3A4CYP2E1CYP2D6 | |
| SCHEMBL14860945 | 0.82 | ASH1L (0.62) | ASH1LPIK3CDPIK3CAPI4KAPI4KB | |
| SCHEMBL31621268 | 0.82 | ASH1L (0.62) | ASH1LPIK3CDPIK3CAPI4KAPI4KB | |
| SCHEMBL189243 | 0.76 | PIK3CD (0.54) | PIK3CDPIP5K1CPIK3CAPI4KAPI4KB | |
| SCHEMBL18202841 | 0.75 | ASH1L (0.51) | ASH1LALDH1A1MAPT | |
| SCHEMBL19608483 | 0.74 | ASH1L (1.00) | ASH1LPIK3CDPIK3CAPI4KAPI4KB | |
| SCHEMBL30311987 | 0.74 | ASH1L (0.54) | ASH1LPIK3CDPIP5K1CPIK3CAPI4KA | |
| SCHEMBL29013231 | 0.74 | ASH1L (0.54) | ASH1LPIK3CDPIP5K1CPIK3CAPI4KA | |
| SCHEMBL34471238 | 0.72 | FTO (0.54) | ASH1LPIK3CDPIP5K1CPIK3CAPI4KA | |
| SCHEMBL2760411 | 0.72 | PIK3CD (0.57) | PIK3CDPIP5K1CPIK3CAPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401273-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2012-01-04 | — | — | EP | disclosed |