Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25083764 | 0.85 | LMNA (0.44) | LMNATDP1NPC1RAB9ATP53 | |
| SCHEMBL1179956 | 0.82 | MAPK8 (0.42) | LMNATDP1ALOX15TSHRHIF1A | |
| SCHEMBL1760192 | 0.77 | LMNA (1.00) | LMNATDP1ALOX15TSHRHIF1A | |
| SCHEMBL1179070 | 0.77 | LMNA (0.68) | LMNATDP1ALOX15TSHRHIF1A | |
| SCHEMBL29305616 | 0.77 | KMO (0.44) | LMNATDP1ALOX15TSHRHIF1A | |
| Hydrochloric Acid SCHEMBL11422692 | 0.75 | LMNA (0.96) | LMNATDP1ALOX15TSHRHIF1A | |
| SCHEMBL4513032 | 0.72 | PTGDR (0.63) | — | |
| SCHEMBL12918535 | 0.72 | NPC1 (0.50) | LMNATDP1NPC1RAB9ATP53 | |
| SCHEMBL18924931 | 0.71 | ALOX15 (0.37) | LMNATDP1ALOX15TSHRHIF1A | |
| SCHEMBL26698986 | 0.71 | MAPT (0.38) | LMNATSHRNPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670222-B2 | CCR2 receptor antagonists and uses thereof | CENTREXION THERAPEUTICS CORPORATION (US) | 2017-06-06 | — | — | US | disclosed |