Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.37 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623066 | 0.85 | YTHDC1 (0.37) | KMOYTHDC1YTHDF2ALDH1A1KDM4E | |
| SCHEMBL13472462 | 0.79 | HCAR3 (0.33) | KMOYTHDC1YTHDF2ALDH1A1KDM4E | |
| SCHEMBL13472317 | 0.79 | KMO (0.39) | KMOYTHDC1YTHDF2HCAR3PDPK1 | |
| SCHEMBL18809682 | 0.79 | SMN1; SMN2 (0.38) | KMOALDH1A1KDM4EHSD17B10MKNK2 | |
| SCHEMBL18809723 | 0.77 | GAA (0.46) | ALDH1A1KDM4EHSD17B10CSNK2A2CSNK2B | |
| SCHEMBL14567010 | 0.76 | YTHDC1 (0.48) | YTHDC1YTHDF2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7763434 | 0.75 | KMO (0.47) | KMOALDH1A1KDM4ECYP3A4HPGD | |
| SCHEMBL12591005 | 0.75 | ADORA2A (0.33) | KMOYTHDC1YTHDF2HCAR3PDPK1 | |
| SCHEMBL2259692 | 0.74 | KMO (0.46) | KMOALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL28069552 | 0.73 | KMO (0.43) | KMOALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670222-B2 | CCR2 receptor antagonists and uses thereof | CENTREXION THERAPEUTICS CORPORATION (US) | 2017-06-06 | — | — | US | disclosed |