Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10177617 | 0.77 | TDP1 (0.41) | LMNATDP1POLBNPSR1GPR35 | |
| SCHEMBL15033718 | 0.72 | MAPT (0.43) | LMNATDP1NPSR1KDM4EMAPT | |
| SCHEMBL21422768 | 0.72 | PAK4 (0.35) | LMNANPSR1ALDH1A1MAPTHTT | |
| SCHEMBL18924957 | 0.71 | PDE4A (0.38) | L3MBTL1ALDH1A1MAPT | |
| SCHEMBL15033784 | 0.71 | CA1 (0.45) | KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL2981405 | 0.67 | NPSR1 (0.41) | LMNATDP1POLBNPSR1GPR35 | |
| SCHEMBL18924951 | 0.66 | KMO (0.43) | KDM4ECYP1A2ALDH1A1MAPT | |
| SCHEMBL9190916 | 0.64 | TDP1 (0.40) | LMNATDP1POLBNPSR1CYP1A2 | |
| SCHEMBL10177621 | 0.64 | CYP1A2 (0.37) | LMNATDP1NPSR1PDE10ACYP1A2 | |
| SCHEMBL22602453 | 0.64 | LMNA (0.40) | LMNATDP1NPSR1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670222-B2 | CCR2 receptor antagonists and uses thereof | CENTREXION THERAPEUTICS CORPORATION (US) | 2017-06-06 | — | — | US | disclosed |