Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 3/20 | 0.59 |
| ▸ | MMP9 | P14780 | 3/20 | 0.59 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.58 |
| ▸ | ITGAL | P20701 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197718 | 1.00 | ACE (0.66) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL9197724 | 1.00 | ACE (0.66) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL24194437 | 0.89 | KMT2A (0.61) | ACEKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL231803 | 0.86 | ALOX15 (0.66) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL231804 | 0.86 | ALOX15 (0.66) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL8347108 | 0.86 | ACE (0.64) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL7558085 | 0.84 | ALOX15 (0.67) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL31210300 | 0.84 | ALOX15 (0.67) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL7558077 | 0.84 | ALOX15 (0.67) | ACEALOX15KMT2AP2RY14POLB | |
| SCHEMBL1060611 | 0.84 | ACE (0.70) | ACEALOX15KMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |