SCHEMBL231804

SCHEMBL231804

CON[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.66
ACE P12821 3/20 0.65
KMT2A Q03164 3/20 0.64
POLB P06746 3/20 0.63
MAPT P10636 3/20 0.63
KDM4E B2RXH2 2/20 0.63
APAF1 O14727 1/20 0.63
RECQL P46063 1/20 0.63
L3MBTL1 Q9Y468 1/20 0.63
ITGB2 P05107 2/20 0.62
ICAM1 P05362 2/20 0.62
ITGAL P20701 2/20 0.62
MMP2 P08253 2/20 0.62
MMP9 P14780 2/20 0.62
SMN1; SMN2 Q16637 2/20 0.60
MEN1 O00255 2/20 0.60
ECE1 P42892 3/20 0.60
P2RY14 Q15391 1/20 0.59
TP53 P04637 1/20 0.59
LMNA P02545 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL231803 1.00 ALOX15 (0.66) ALOX15ACEKMT2APOLBMAPT
SCHEMBL4721738 0.88 ECE1 (0.60) ALOX15ACEKMT2APOLBMAPT
SCHEMBL7558077 0.87 ALOX15 (0.67) ALOX15ACEKMT2APOLBMAPT
SCHEMBL31210300 0.87 ALOX15 (0.67) ALOX15ACEKMT2APOLBMAPT
SCHEMBL7558085 0.87 ALOX15 (0.67) ALOX15ACEKMT2APOLBMAPT
SCHEMBL9197718 0.86 ACE (0.66) ALOX15ACEKMT2APOLBMAPT
SCHEMBL18925577 0.86 ACE (0.66) ALOX15ACEKMT2APOLBMAPT
SCHEMBL9197724 0.86 ACE (0.66) ALOX15ACEKMT2APOLBMAPT
SCHEMBL11369419 0.86 ALOX15 (0.72) ALOX15ACEKMT2APOLBITGB2
SCHEMBL28648798 0.86 MMP2 (0.62) ALOX15ACEKMT2APOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117343854-A Yarrowia lipolytica engineering bacterium for synthesizing N-acetyl-5 methoxy tryptamine by using 5-hydroxytryptophan as substrate and application thereof 河北维达康生物科技有限公司 2024-01-05 CN claimed
CN-103776914-A Biomarker of male infertility in unknown aetiology and application method of biomarker INST URBAN ENVIRONMENT CAS 2014-05-07 CN claimed
EP-4747882-A1 DATA STORAGE USING PROTEINS The Hong Kong Polytechnic University (CN) 2026-05-27 EP disclosed
US-12383628-B2 Hydrogel-forming composition for controlled release VRIJE UNIVERSITEIT BRUSSEL (BE) 2025-08-12 US disclosed
US-12319946-B2 Methods for producing modified bacteria for production of nitroaromatics UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2025-06-03 US disclosed
CN-112313749-B Data storage using peptides 香港理工大学 2025-02-07 CN disclosed
EP-3776557-B1 DATA STORAGE USING PEPTIDES UNIV HONG KONG POLYTECHNIC (CN) 2025-01-29 EP disclosed
WO-2025015598-A1 DATA STORAGE USING PROTEINS THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2025-01-23 WO disclosed
US-20240417764-A1 METHODS FOR THE PRODUCTION OF TRYPTOPHANS, TRYPTAMINES, INTERMEDIATES, SIDE PRODUCTS AND DERIVATIVES MIAMI UNIVERSITY 2024-12-19 US disclosed
EP-4426676-A2 METHODS FOR THE PRODUCTION OF TRYPTOPHANS, TRYPTAMINES, INTERMEDIATES, SIDE PRODUCTS AND DERIVATIVES MIAMI UNIVERSITY (US) 2024-09-11 EP disclosed
US-20240229090-A1 MODIFIED BACTERIA FOR PRODUCTION OF NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-07-11 US disclosed
US-7163671-B2 Long-term stabilized formulations CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2007-01-16 US disclosed
US-20060160884-A1 Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase WYETH (US) 2006-07-20 US disclosed
WO-2004087795-A1 AUTHENTICATION MEANS UCB, S.A. (BE) 2004-10-14 WO disclosed
US-20030092622-A1 Preparation stabilized over long time CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-05-15 US disclosed
US-20030044909-A1 Melatonin-receptor expression cells and thier uses JCR PHARMACEUTICALS CO., LTD. (JP) 2003-03-06 US disclosed
EP-1260230-A1 PREPARATIONS STABILIZED OVER LONG TIME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-11-27 EP disclosed
EP-0892046-A2 Melatonin-receptor expression cells and their uses JCR PHARMACEUTICALS Co., LTD. (JP) 1999-01-20 EP disclosed
US-4360594-A REACTING INDOLE COMPOUND WITH SERINE, OR WITH PYRUVIC ACID AND AMMONIUM ION ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1982-11-23 US disclosed
US-4349627-A Process for producing L-tryptophan or derivatives thereof using a microorganism ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1982-09-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160884-A1 Alkynyl-containing tryptophan derivative inhibitors of tace/matrix metalloproteinase ADAM17, TPSAB1, ADAM10 ALOX15 635/4885ACE 157/4885KMT2A 1950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.