Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.56 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.56 |
| ▸ | ITGAL | P20701 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ECE1 | P42892 | 3/20 | 0.54 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 3/20 | 0.54 |
| ▸ | MMP9 | P14780 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31210300 | 0.87 | ALOX15 (0.67) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL18925577 | 0.86 | ACE (0.66) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL9197724 | 0.86 | ACE (0.66) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL9197718 | 0.86 | ACE (0.66) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL231803 | 0.84 | ALOX15 (0.66) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL231804 | 0.84 | ALOX15 (0.66) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL7558085 | 0.82 | ALOX15 (0.67) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL5189433 | 0.82 | ACE (0.82) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL8466953 | 0.82 | ACE (0.82) | ACEALOX15ITGB2ICAM1ITGAL | |
| SCHEMBL7558077 | 0.82 | ALOX15 (0.67) | ACEALOX15ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869489-A | TREATMENT OF INFLAMMATORY DISEASES, MIGRAINES AND ASTHMA | MERCK & CO., INC. (US) | 1999-02-09 | — | — | US | disclosed |