Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18928973 | 0.91 | NR1I2 (0.34) | NR1I2PDE4APTGDR2 | |
| SCHEMBL18928449 | 0.87 | NR1I2 (0.33) | NR1I2PDE4A | |
| SCHEMBL18928129 | 0.83 | NR1I2 (0.35) | NR1I2PDE4AKCNH2PTGDR2 | |
| SCHEMBL18928972 | 0.82 | NR1I2 (0.33) | HTR4NR1I2PTGDR2 | |
| SCHEMBL18663914 | 0.81 | NR1I2 (0.37) | NR1I2 | |
| SCHEMBL18944148 | 0.80 | NR1I2 (0.38) | NR1I2 | |
| SCHEMBL18928273 | 0.80 | NR1I2 (0.32) | NR1I2PDE4A | |
| SCHEMBL18920149 | 0.80 | NR1I2 (0.49) | NR1I2PDE4AKCNH2 | |
| SCHEMBL18664243 | 0.79 | NR1I2 (0.36) | NR1I2 | |
| SCHEMBL18928302 | 0.79 | LMNA (0.40) | NR1I2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017093938-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | VIIV HEALTHCARE UK LIMITED (GB) | 2017-06-08 | — | — | WO | disclosed |