Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.72 |
| ▸ | HPGD | P15428 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | PPARG | P37231 | 1/20 | 0.72 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.72 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 12/20 | 0.70 |
| ▸ | HTT | P42858 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 9/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.68 |
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.66 |
| ▸ | CFTR | P13569 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30514599 | 1.00 | KDM4E (0.72) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL190236 | 0.90 | KDM4E (0.71) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL188898 | 0.88 | MAPT (0.72) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL189642 | 0.85 | ALDH1A1 (0.83) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL24074827 | 0.84 | KDM4E (1.00) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL30514598 | 0.84 | KDM4E (1.00) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL27838813 | 0.80 | PIK3CA (1.00) | KDM4EHPGDMAPTALDH1A1MEN1 | |
| SCHEMBL189476 | 0.79 | MAPT (0.84) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL15457559 | 0.79 | ALDH1A1 (0.76) | KDM4EHPGDTSHRPPARGNCOA2 | |
| SCHEMBL190020 | 0.78 | MAPT (0.71) | KDM4EHPGDTSHRPPARGNCOA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-B9 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-09-26 | — | — | EP | claimed |
| EP-2056829-B1 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-01-04 | — | — | EP | claimed |
| US-20230241074-A1 | INHIBITORS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS | Atomwise Inc. | 2023-08-03 | — | — | US | disclosed |
| US-20230241074-A1 | INHIBITORS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS | Atomwise Inc. | 2023-08-03 | — | — | US | disclosed |
| US-20230241074-A1 | INHIBITORS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS | Atomwise Inc. | 2023-08-03 | — | — | US | disclosed |
| WO-2021243118-A1 | INHIBITORS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS | UNIVERSITY OF CONNECTICUT (US) | 2021-12-02 | — | — | WO | disclosed |
| US-20140100215-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2014-04-10 | — | — | US | disclosed |
| US-8642584-B2 | Method of using PI3K and MEK modulators | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642584-B2 | Method of using PI3K and MEK modulators | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642584-B2 | Method of using PI3K and MEK modulators | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120302545-A1 | Method of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2012-11-29 | — | — | US | disclosed |
| US-20120302545-A1 | Method of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2012-11-29 | — | — | US | disclosed |
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | KDM4E 761/4885HPGD 2378/4885TSHR 2801/4885 |
| US-20230241074-A1 | INHIBITORS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS | MAVS, PIGS, SARS1 | KDM4E 3317/4885HPGD 2433/4885TSHR 3920/4885 |
| US-20140100215-A1 | Methods of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | KDM4E 761/4885HPGD 2378/4885TSHR 2801/4885 |
| US-20120302545-A1 | Method of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | KDM4E 729/4885HPGD 2180/4885TSHR 2458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.