Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Uric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uric Acid SCHEMBL17185561 | 0.93 | GDA (0.80) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL27816624 | 0.93 | GDA (0.89) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL28093010 | 0.88 | GDA (0.73) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL3417988 | 0.87 | GDA (1.00) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL1331321 | 0.87 | GDA (1.00) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL22069923 | 0.87 | GDA (1.00) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL822247 | 0.86 | GDA (0.76) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL10631703 | 0.85 | GDA (0.94) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL229866 | 0.85 | GDA (0.94) | GDAALDH1A1CYP1A2CYP2C9HPGD | |
| Uric Acid SCHEMBL2434620 | 0.85 | GDA (0.94) | GDAALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2503882-A1 | AMIDOACETONITRILE COMPOUNDS HAVING PESTICICAL ACTIVITY | Novartis AG (CH) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011061326-A1 | AMIDOACETONITRILE COMPOUNDS HAVING PESTICICAL ACTIVITY | NOVARTIS AG (CH) | 2011-05-26 | — | — | WO | disclosed |