Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Uric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.73 |
| ▸ | TYMP | P19971 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uric Acid SCHEMBL17185561 | 0.91 | GDA (0.80) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL27816624 | 0.91 | GDA (0.89) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL8330954 | 0.89 | GDA (0.70) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL22069923 | 0.85 | GDA (1.00) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL822247 | 0.84 | GDA (0.76) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL229866 | 0.83 | GDA (0.94) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL16213309 | 0.83 | GDA (0.94) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL10631703 | 0.83 | GDA (0.94) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL2434620 | 0.83 | GDA (0.94) | GDATYMPALDH1A1CYP1A2CYP2C9 | |
| Uric Acid SCHEMBL11423974 | 0.83 | GDA (0.94) | GDATYMPALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113475668-A | Biomass formulation | 帝斯曼知识产权资产管理有限公司 | 2021-10-08 | — | — | CN | claimed |
| CN-113660980-A | Carotenoids for use in the treatment or prevention of nausea | 通用医疗公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-113475668-A | Biomass formulation | 帝斯曼知识产权资产管理有限公司 | 2021-10-08 | — | — | CN | disclosed |
| CN-106232578-B | From the method for the biologic artifact separation carotenoid of production carotenoid | 帝斯曼知识产权资产管理有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-107532135-A | The micro-organisms of terpenoid | 帝斯曼知识产权资产管理有限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-106232578-A | Method from the biologic artifact separation carotenoid producing carotenoid | 帝斯曼知识产权资产管理有限公司 | 2016-12-14 | — | — | CN | disclosed |