Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18935520 | 0.92 | BRD4 (0.49) | MTNR1AMTNR1BBRD4CCNCCDK8 | |
| SCHEMBL3417837 | 0.87 | MTNR1A (0.50) | MTNR1AMTNR1BMAPK1BRD4USP2 | |
| SCHEMBL18917701 | 0.85 | MTNR1A (0.48) | MTNR1AMTNR1BMAPK1USP2CYP1A2 | |
| SCHEMBL9009161 | 0.84 | MTNR1A (0.47) | MTNR1AMTNR1BMAPK1CYP1A2CYP3A4 | |
| SCHEMBL3414187 | 0.84 | BRD4 (0.49) | MTNR1AMTNR1BMAPK1BRD4SMN1; SMN2 | |
| SCHEMBL23116611 | 0.84 | MAPK1 (0.67) | MTNR1AMTNR1BMAPK1USP2CYP1A2 | |
| SCHEMBL31130021 | 0.82 | MTNR1A (0.44) | MTNR1AMTNR1BMAPK1BRD4CYP1A2 | |
| SCHEMBL3414185 | 0.82 | MTNR1A (0.46) | MTNR1AMTNR1BMAPK1BRD4USP2 | |
| SCHEMBL21389502 | 0.81 | DRD2 (0.42) | BRD4CCNCCDK8ALDH1A1 | |
| SCHEMBL20436342 | 0.81 | HTR2A (0.45) | MTNR1AMTNR1BHTR2AHTR2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KRAS, HRAS, NRAS | MTNR1A 3940/4885MTNR1B 3925/4885MAPK1 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.