Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 6/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326192 | 0.83 | HPGD (0.41) | HPGDALDH1A1MAPK1CYP3A4MAPT | |
| SCHEMBL2092525 | 0.82 | ALDH1A1 (0.35) | HPGDALDH1A1MAPK1CYP3A4MAPT | |
| SCHEMBL1406514 | 0.80 | ALDH1A1 (0.48) | HPGDALDH1A1MAPK1CYP3A4MAPT | |
| SCHEMBL1975862 | 0.78 | KDM4E (0.50) | HPGDALDH1A1MAPK1CYP3A4MAPT | |
| SCHEMBL6340582 | 0.78 | SMN1; SMN2 (0.35) | HPGDALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL28755746 | 0.78 | GAA (0.40) | HPGDKDM4EPOLBGAASMN1; SMN2 | |
| SCHEMBL4322097 | 0.78 | L3MBTL1 (0.40) | HPGDALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL3334103 | 0.78 | LMNA (0.55) | HPGDALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL1206852 | 0.77 | KMT2A (0.38) | ALDH1A1KMT2AKDM4EGAASMN1; SMN2 | |
| SCHEMBL441463 | 0.77 | MAPK1 (0.33) | ALDH1A1MAPK1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | claimed |
| EP-2398791-A1 | INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS | Amgen, Inc (US) | 2011-12-28 | — | — | EP | claimed |
| WO-2010096314-A1 | INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS | AMGEN INC. (US) | 2010-08-26 | — | — | WO | claimed |
| EP-0485984-B1 | Diarylmethoxypiperidine derivatives | UBE INDUSTRIES (JP) | 1996-04-24 | — | — | EP | claimed |
| EP-0485984-A2 | Diarylmethoxypiperidine derivatives | UBE INDUSTRIES, LTD. (JP) | 1992-05-20 | — | — | EP | claimed |
| CN-1042153-A | 3-aryloxy methyl-cephalosporins derivatives, their preparation and purposes pharmaceutically | SANKYO CO (JP) | 1990-05-16 | — | — | CN | claimed |
| EP-0363223-A2 | 3-Aryloxymethyl-cephalosporin derivatives, their preparation and their medical use | Sankyo Company Limited (JP) | 1990-04-11 | — | — | EP | claimed |
| EP-0131221-B1 | THIOETHERS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1987-01-28 | — | — | EP | claimed |
| US-4621098-A | Thioethers and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1986-11-04 | — | — | US | claimed |
| CN-107207694-B | Urethane (meth) acrylate resin, curable resin composition, cured product thereof, and plastic lens | DIC株式会社 | 2020-08-07 | — | — | CN | disclosed |
| US-10640603-B2 | Urethane (meth)acrylate resin, curable resin composition, cured product thereof, and plastic lens | DIC CORPORATION (JP) | 2020-05-05 | — | — | US | disclosed |
| US-10066042-B2 | Photocurable resin composition, cured product thereof, and plastic lens | DIC CORPORATION (JP) | 2018-09-04 | — | — | US | disclosed |
| US-20180030198-A1 | URETHANE (METH)ACRYLATE RESIN, CURABLE RESIN COMPOSITION, CURED PRODUCT THEREOF, AND PLASTIC LENS | DIC CORPORATION (JP) | 2018-02-01 | — | — | US | disclosed |
| US-20170145137-A1 | PHOTOCURABLE RESIN COMPOSITION, CURED PRODUCT THEREOF, AND PLASTIC LENS | DIC CORPORATION (JP) | 2017-05-25 | — | — | US | disclosed |
| EP-0485984-B1 | Diarylmethoxypiperidine derivatives | UBE INDUSTRIES (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5389626-A | 3-aryloxmethyl-cephalosporin derivatives, and their medical use | SANKYO COMPANY, LIMITED (JP) | 1995-02-14 | — | — | US | disclosed |
| US-5225559-A | DIARYLMETHOXYPIPERIDINE DERIVATIVES | UBE INDUSTRIES, LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0485984-A2 | Diarylmethoxypiperidine derivatives | UBE INDUSTRIES, LTD. (JP) | 1992-05-20 | — | — | EP | disclosed |
| CN-1042153-A | 3-aryloxy methyl-cephalosporins derivatives, their preparation and purposes pharmaceutically | SANKYO CO (JP) | 1990-05-16 | — | — | CN | disclosed |
| EP-0363223-A2 | 3-Aryloxymethyl-cephalosporin derivatives, their preparation and their medical use | Sankyo Company Limited (JP) | 1990-04-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | MTOR, PIKFYVE, RICTOR | HPGD 2732/4885ALDH1A1 4371/4885MAPK1 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.