Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 7/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21388440 | 0.83 | HCAR3 (0.50) | GBA1HCAR3HDAC6CCR1CCR5 | |
| SCHEMBL23183031 | 0.83 | GBA1 (0.50) | GBA1HCAR3HDAC6CCR1CCR5 | |
| SCHEMBL179288 | 0.82 | GBA1 (0.62) | GBA1HCAR3HDAC6CCR1CCR5 | |
| SCHEMBL12394221 | 0.80 | HCAR3 (0.46) | GBA1HCAR3HDAC6CCR1CCR5 | |
| SCHEMBL13879816 | 0.77 | HCAR3 (0.51) | GBA1HCAR3HDAC6CCR1CCR5 | |
| SCHEMBL20056973 | 0.75 | HCAR3 (0.57) | GBA1HCAR3HDAC6CCR1CCR5 | |
| SCHEMBL11567147 | 0.73 | GBA1 (0.47) | GBA1AOC3CRHR1 | |
| SCHEMBL11566506 | 0.72 | GBA1 (0.45) | GBA1HCAR3MAPTCRHR1 | |
| SCHEMBL21241060 | 0.71 | GBA1 (0.45) | GBA1HCAR3HDAC6CCR1CCR5 | |
| SCHEMBL16258696 | 0.70 | HCAR3 (0.47) | GBA1HCAR3HDAC6CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3392252-B1 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | LIBERTAS BIO INC (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-2748166-B1 | PYRIMIDO-PYRIDAZINONE COMPOUNDS AND USE THEREOF | ASANA BIOSCIENCES LLC (US) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017095898-A1 | USES OF PYRIMIDO-PYRIMIDAZINONES TO TREAT CANCER | ASANA BIOSCIENCES, LLC (US) | 2017-06-08 | — | — | WO | disclosed |