Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | FPR3 | P25089 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28679080 | 0.88 | USP30 (0.48) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL28679078 | 0.88 | USP30 (0.48) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL529396 | 0.88 | USP30 (0.49) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL29518151 | 0.88 | USP30 (0.48) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL889050 | 0.88 | FPR2 (0.53) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL1030155 | 0.88 | FPR2 (0.53) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL19749791 | 0.87 | ALDH1A1 (0.54) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL2419028 | 0.86 | ALDH1A1 (0.57) | USP30DDB1CRBNJAK1ALDH1A1 | |
| SCHEMBL27696270 | 0.86 | USP30 (0.48) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL1120230 | 0.85 | CYP3A4 (0.52) | USP30PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925721-B1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN MA INC (US) | 2017-06-07 | — | — | EP | disclosed |