Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28679078 | 1.00 | USP30 (0.48) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL28679080 | 1.00 | USP30 (0.48) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL18937698 | 0.88 | USP30 (0.49) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL889050 | 0.87 | FPR2 (0.53) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL1030155 | 0.87 | FPR2 (0.53) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL529396 | 0.87 | USP30 (0.49) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL29518225 | 0.86 | ALDH1A1 (0.56) | USP30DDB1CRBNJAK1ALDH1A1 | |
| SCHEMBL22825511 | 0.86 | ALDH1A1 (0.56) | USP30DDB1CRBNJAK1ALDH1A1 | |
| SCHEMBL19749791 | 0.86 | ALDH1A1 (0.54) | USP30HDAC4HDAC6DDB1CRBN | |
| SCHEMBL31227721 | 0.85 | USP30 (0.49) | USP30HDAC4HDAC6PARP1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12325696-B2 | Indazole derivative, preparation method therefor, and pharmaceutical application thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2025-06-10 | — | — | US | disclosed |
| US-20220267304-A1 | INDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2022-08-25 | — | — | US | disclosed |
| EP-3988547-A1 | INDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2022-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12325696-B2 | Indazole derivative, preparation method therefor, and pharmaceutical application thereof | CYP19A1, HSD17B11, CYP51A1 | USP30 3873/4885HDAC4 1862/4885HDAC6 2767/4885 |
| US-20220267304-A1 | INDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | CYP19A1, HSD17B11, CYP51A1 | USP30 3873/4885HDAC4 1862/4885HDAC6 2767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.